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New Antibody: Cytokeratin 17

CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is
found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages.

Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Contact us or your local distributor for ordering information:

0.1 ml format, MON5154-01
1.0 ml format, MON5154-1
7.0 ml format, MON-RTU5154

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