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NEW MONOSAN Xtra ANTIBODIES

CD19 Clone BT51E Cat. no. MONX11112

CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. It is a single chain glycoprotein present on the surface of B lymphocytes and follicular dendritic cells of the hematopoietic system. CD19 is a crucial regulator in B cell development, activation and differentiation. On B cells, CD19 associates with CD21, CD81 and CD225 (Leu-13) forming a signal transduction complex. CD19 is expressed from the earliest recognizable B cell lineage stage, through development to B cell differentiation but is lost on maturation to plasma cells.

CD99 Clone PCB1 Cat. no. MONX11129

CD99 is a 32 kDa transmembrane glycoprotein, encoded by the MIC2 gene, which is located in the pseudoautosomal region of the human X and Y chromosomes. Recently, the MIC2 gene has been shown to encode two distinct proteins which are produced by alternative splicing of the CD99 gene transcript and are identified as bands of 30 and 32 kDa (p30/32).Although its function is not fully understood, CD99 has been implicated in various cellular processes including homotypic aggregation of T cells, upregulation of T cell receptor and MHS molecules, apoptosis of immature thymocytes and leukocyte diapedesis. CD99 is reported to be expressed on most human tissues including cortical thymocytes, pancreatic islets cells, Leydig and Sertoli cells, virtually all hematopoietic cell types (except granulocytes), peripheral blood lymphocytes, granulose cells of the ovary, endothelial cells and basal/parabasal squamous epithelial cells. CD99 expression has been reported in a wide range of tumors, including Ewings sarcoma and T cell lymphoma.

Oct 3/4 Clone N1NK Cat. no. MONX11104

Oct3/4 is a member of the POU homeodomain family of transcription factors, which is expressed by embryonic stem cells and germ cells. A critical amount of Oct3/4 levels are associated with loss of pluripotency. Oct3/4 has been proposed as a useful marker for germ cell tumors which exhibit features of pluripotentiality, including seminoma/dysgerminoma and embryonal carcinoma, and establishing a germ cell origin for some metastatic tumors of uncertain primary tumor.

Multiple Myeloma Oncogene 1 (MUM/1) Clone EAU32 Cat. no. MONX11127

The MUM-1 (multiple myeloma oncogene 1) gene was originally identified because of its involvement in the t(6:14) translocation observed in multiple myeloma, which causes the juxtaposition of the MUM-1 gene to the Ig heavy chain locus. MUM-1 is expressed in late plasma cell directed stages of Bcell differentiation and in activated T cells, suggesting that MUM-1 may serve as a marker for lympho-hemopoetic neoplasms derived from these cells. The morphologic spectrum of MUM-1 expressing cells has been found to range from that of a centrocyte to that of a plasmablast/plasma cell. Consequently the histogenic value of MUM-1 may be to provide a marker to aid in the identification of the transition from BCL-6 positive (germinal center B cells) to CD138 positive (immunoblasts and plasma cells). MUM-1 expression occurs in a wide range of lymphoid neoplasms including a proportion of diffuse B cell lymphomas but not myeloid or extra-hemopoietic neoplasms. MUM-1 is consistently expressed in myeloma cells, Reed Sternberg cells in classic Hodgkin Disease, and activated and neoplastic Tcells. 

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