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New Monosan products, anti-HGAL antibodies!

We are pleased to announce the release of HGAL for the detection of follicular lymphoma. This RUO antibody is available as concentrate or predilute (ready to use). Monosan's HGAL is compatible with most automated staining platforms.

HGAL is a mouse monoclonal antibody that has the highest sensitivity of all established diagnostic markers (CD10, bcl6, and bcl2) for follicular lymphoma.  It marks both follicular components and the diffuse interfollicular components that other markers are not sensitive enough to detect.  CD10 and bcl6 have been more difficult antibodies to work with on lymphoid tissues, but HGAL doesn’t share this laborious characteristic.  The high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas.

MON3368
1.0ml concentrate
Dilution range: 1:100-1:500

MON-RTU1249  
7.0ml predilute
Dilution range: Ready to use

References:

1. Natkunam, Y et al. Expression of the human germinal center-associated lymphoma (HGAL) protein, a new marker of germinal center B-cell derivation. Blood 2005; 105:3979–3986.

2. Natkunam, Y et al. Expression of the human germinal center-associated lymphoma (HGAL) protein identifies a subset of classic Hodgkin lymphoma of germinal center derivation and improved survival. Blood 2007; 109:298-305.

3. Younes, SF et al. Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components. Am J Surg Pathol 2010; 34:1266-1276.

4. Higgins, RA et al. Application of immunohistochemistry in the diagnosis of non-Hodgkin and Hodgkin lymphoma. Arch Pathol Lab Med 2008; 132:441-446.

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