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Cellular Fibronectin
Fibronectins (Fns) are large glycoproteins present both insoluble in extracellular matrix (ECM) and soluble in various body fluids. The tissue form is called cellular fibronectin (cFn) and the soluble form plasma fibronectin (pFn). Fns have a role in various phenomena such as tissue organization, cell adhesion, differentiation, as well as tumor invasion and metastasis.
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Cytokeratin 34betaE12 vs. Cytokeratin 5&14
Advantages of CK 5 & 14
The detection of PIN (prostate intraepithelial neoplasia) involves distinguishing the neoplastic tissue in prostate biopsies (commonly detected with the P504s/Racemase antibody) from the benign glandular tissue (commonly detected with a high molecular weight cytokeratin or p63 antibody). Historically, the most commonly used high molecular weight keratin for labeling benign prostate glands has been Cytokeratin 34betaE12, also known as Cytokeratin 903. This can possibly be attributed to Cytokeratin 34betaE12 being one of the earliest and most widely published clones to be cited for use in labeling benign prostate myoepithelial cells.
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Monosan Ready to Use
To reduce histopathology workflows and eliminating the variability of immunostaining, Monosan designed a prediluted antibody line named Monosan Ready-to-Use. This RTU line contains more than 200 new antibody products for immunohistochemical (IHC) use on frozen and FFPE tissue sections. The 7ml. and 15ml monoclonals (rabbit and mouse) and polyclonals are applicable for fully automated IHC systems and manual use.
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