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Cytokeratin 34betaE12 vs. Cytokeratin 5&14
Advantages of CK 5 & 14
The detection of PIN (prostate intraepithelial neoplasia) involves distinguishing the neoplastic tissue in prostate biopsies (commonly detected with the P504s/Racemase antibody) from the benign glandular tissue (commonly detected with a high molecular weight cytokeratin or p63 antibody). Historically, the most commonly used high molecular weight keratin for labeling benign prostate glands has been Cytokeratin 34betaE12, also known as Cytokeratin 903. This can possibly be attributed to Cytokeratin 34betaE12 being one of the earliest and most widely published clones to be cited for use in labeling benign prostate myoepithelial cells.
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